Saturday, September 17, 2011

Preparation of the Root canal System- Endodontics Lecture note

INTRODUCTION

The key factor in the development of pulpal inflammation and apical periodontitis is the presence of bacteria. It has been widely accepted that bacteria and/or their products are the main aetiological factors in the initiation and progress of these diseases. Consequently, the central focus of root canal treatment has been directed towards the elimination of bacteria and their substrates from the pulp canal system. This may involve removal of necrotic pulp and tissue debris, removal of an inflamed pulp or, in elective treatment, the removal of healthy tissue. Historically, a mechanistic approach to root canal treatment was frequently adopted, but in recent years a greater awareness of the complexities of the root canal system has led to the development of newer techniques, instruments and materials. These new developments have greatly enhanced the clinician’s ability to achieve the biologically-based objectives of root canal treatment, which include: 

1. Removal of all tissue, bacteria and bacterial products and substrates from the root canal system.
2. Shaping of the root canal system to facilitate placement of a root canal filling.
3. filling of the shaped canal system coupled with an adequate and timely coronal restoration.

A root end which has been made transparent showing two lateral canals

Traditionally the ‘endodontic triad’ concept of cleaning, shaping and filling has been promulgated widely. However, considering that a major goal of root canal treatment is removal of microorganisms from the complex root canal system, it would therefore appear that ‘shaping to facilitate cleaning and filling’ might be a more appropriate concept. These objectives must be achieved while ensuring conservation of tooth structure and maintaining canal shape.

PREOPERATIVE ASSESSMENT

Once a diagnosis has confirmed the need for root canal treatment, then a treatment plan that includes the marginal periodontal status and restorability of the tooth is essential before treatment commences. In addition to the clinical examination this assessment includes radiological evaluation of the tooth. Good quality preoperative radiographs (preferably from two different angles) are indicated. These films must not be distorted, and must be processed properly to ensure a permanent record. Alternatively, digital radiographs should be filed and a permanent copy stored. Use of a paralleling technique and a film-holder will minimize distortion of the radiograph and facilitate accurate preoperative, postoperative and review comparisons. Periapical films are the radiographic views most frequently used during root canal treatment. However, other intraoral and extraoral views can often contribute to the overall preoperative assessment and to diagnosis. These additional films include bitewing, panoramic and occlusal films. For example, a supplemental bitewing radiograph may be useful in detecting suspected caries not readily visible on the periapical radiograph or to determine the relationship of the pulp chamber to the external surface of the tooth. The tooth to be treated should be located centrally on the periapical film with at least 2 mm of periradicular tissue visible beyond and around the apex. A subsequent film should be exposed with the X-ray beam angled 15o–20o to the original exposure. This shift in angulation results in an apparent change in the position of the roots and is called the parallax effect. Both horizontal and vertical parallax techniques can be used. A good quality film will provide information concerning the general tooth form and the relationship of the tooth to the surrounding structures. Furthermore it will reveal evidence about the number of roots, their length, and the relationship of the roots to the crown of the tooth. Moreover, it can provide details of previous dental disease and treatment, as well as the resultant pulp reactions such as narrowing of the pulp chamber and root canals or presence of pulp calcifications. However, interpretation of radiographs can be misleading if certain concepts are not understood; for example, teeth with irreversibly inflamed or necrotic pulps frequently show no radiological changes. Likewise radiological evidence of periradicular lesions may not become obvious until the dense cortical plate of bone has undergone some resorption.



Two radiographs of the maxillary second premolar taken from different angles: (a) a single root canal filling is observed in the buccal root canal; (b) the two root canals are superimposed on each other but the periapical radiolucency is clearly seen


A bitewing radiograph (a) clearly shows dental caries on the distal surface of the maxillary second premolar, whereas it is far less clear on the periapical radiograph (b).

The radicular anatomy of teeth is variable, as is the relationship of the roots to the surrounding bone. Anumber of anatomical structures overlie the roots such as the zygomatic arch, mandibular and maxillary tori and the maxillary sinus; they frequently confuse radiological interpretation of the image. It must be appreciated that a radiograph is merely a two-dimensional shadow of a threedimensional object. In addition, interpretation of radiographs has been shown to be highly subjective. During the preoperative assessment it may become evident that a tooth requires coronal buildup, crown lengthening or extrusion before a rubber dam clamp can be placed and root canal treatment started. Localized periodontal surgical procedures or electrosurgery are recommended frequently when caries or fractures extend more than 2–3mm subgingivally. Before the tooth can be restored adequately, a sound dentine margin should protrude at least 1 mm above the free gingival margin that is normally 1–2 mm from the sulcus depth. This implies that the dentine margin should be approximately 3 mm above the crestal bone. The combined connective tissue and epithelial attachment from the crest of the alveolar bone to the base of the gingival sulcus is called the biological width. It is important that restorations do not encroach on this normal soft tissue attachment.

PREPARATION OF THE CLINICAL CROWN
Preliminary procedures involve isolation of the tooth and removal of all dental caries. Existing restorations may need to be removed completely especially if defective. Even if dental caries does not dictate the complete removal of the restoration, it is often beneficial to do so as hidden fracture lines in the proximal areas become visible. If cast restorations are present, it is important to assess the integrity of the restoration and its cement lute, and to decide whether to retain or to remove the restoration. If the tooth is at risk of fracture, a provisional crown or an orthodontic band should be placed prior to treatment. Orthodontic bands provide an excellent option when there has been extensive loss of coronal tooth tissue. These bands are supplied in a wide variety of sizes and are readily adjusted and cemented to the existing tooth structure. Failure to prepare the crown adequately prior to root canal treatment can result in:
Bacterial contamination from saliva or caries during or between treatments;
Displacement of restorative materials into the canal;
Fracture of unsupported tooth structure between visits or after treatment.


The maxillary premolar (a) shows a crack in the floor of the mesial box after removal of the restoration and staining; (b) the mandibular molar shows a crack on the distal aspect after removal of the crown and staining.

Isolation of the tooth with rubber dam is a necessary prerequisite for endodontic treatment. It is essential for protection of the airway. The inhalation or swallowing of instruments by a patient in the absence of rubber dam is a serious but preventable accident and is indefensible. The rubber dam application technique is a matter of choice for the individual clinician. A wide variety of clamps are available but a skilled clinician will normally use a limited range. Winged clamps are most suitable for the fast and efficient placement of rubber dam. These winged clamps allow the dentist to place the clamp, dam and frame in one action. In recent years an increasing number of reports of allergies to latex have been reported and therefore non-latex rubber dam has been developed.

A complete dam placement kit should include:
Rubber dam;
Rubber dam punch;
clamp forceps;
Selection of clamps;
Dental floss;
caulking agent.

Occasional improvization is necessary when routine rubber dam placement proves difficult. Examples include cases where the tooth in question has undergone extensive coronal tissue loss or where the tooth to be treated is the abutment for a fixed bridge. These situations frequently necessitate clamping an adjacent tooth and stretching the dam over the tooth to be treated, using a ‘split-dam’ technique. Following placement, minor defects in the adaptation of the dam can be corrected with a caulking agent such as OraSeal (Ultradent, Salt Lake City, UT, USA) or cyanoacrylate. Excellent reviews of rubber dam placement have been published. In general, rubber dam application prior to endodontic treatment should be a simple procedure and will enhance both treatment and patient comfort.

A winged clamp allows fast and efficient placement of rubber dam, in this case on a mandibular molar.

In the split-dam technique the right central incisor has been clamped and the dam stretched over the left lateral incisor to allow isolation of the left central incisor

ACCESS CAVITY
The main function of the access cavity is to create an unimpeded pathway to the pulp space and the apical foramen of the tooth. Many problems encountered during root canal treatment can be avoided or eliminated by a properly designed access opening. The major consideration in all access openings is that conservation of coronal tooth structure should never preclude the proper design and purpose of the access opening. The design of the access cavity to the pulp chamber should reflect the anticipated position of the underlying root canal orifices. The relationship between the pulp chamber and external anatomical outlines must be assessed on the preoperative radiographs. Careful analysis of the radiographs and careful alignment of the bur will reduce the possibility of mishaps during access preparation. Inadvertent overextension of a bur either vertically through the floor of the chamber into the furcation or laterally can be prevented by taking these precautions. Occasionally, in cases where an extracoronal restoration is severely tilted relative to the roots or in cases with sclerosed root canal systems, access to the pulp canal chamber may best be created prior to placing rubber dam to permit more accurate orientation of the rotary instruments to the root outline. The pulp chamber must be completely unroofed. The pulp chamber dimensions can vary enormously and reflect the nature of the ‘insults’ that the tooth suffered since eruption. In addition, mineralized deposits are frequently found in the chamber and root canal system. A well-designed access cavity permits:

complete debridement of the pulp chamber;
Visualization of its floor;
Unimpeded placement of instruments into the root canals;
Conservation of tooth tissue.
Coronal and cervical obstructions that may have a restrictive effect on canal exploration and instrumentation need to be eliminated.
Irrigation of the pulp chamber with sodium hypochlorite (NaOCl) during access cavity preparation is used to dissolve tissue and aid in debridement of the chamber. This will also reduce the opportunity for the inadvertent inoculation of microorganisms from the pulp chamber into the root canal system. Ultrasonically energized tips are useful adjuncts during debridement of the pulp chamber to break up calcific masses with relative safety and to facilitate removal of debris. These instruments are contra-angled to enhance access.

Alignment of the bur on the preoperative radiograph will indicate the position and depth of the restoration and pulp chamber.

There are mineralized deposits in the pulp chambers of the canine and first premolar

ROOT CANAL ORIFICES
A sound knowledge of the anatomy of the tooth is very important to the practice of predictable and successful endodontics. The number of canals and their approximate positions can be predicted from a knowledge of dentinogenesis and the nature of root formation. No technological advances or innovations can fully compensate for a lack of understanding of the anatomical features of the pulp chamber, which along with the root canal space are always located in the cross-sectional centre of the crown and root respectively. The location of canal orifices is best achieved with good illumination and a dry pulp floor. Magnification with either loupes or a microscope is usually considered beneficial; however the microscope is better for detecting orifices. Careful inspection of the floor will usually reveal anatomical ‘guidelines’ that will facilitate identification of the orifices even in calcified cases. If the orifice is not immediately apparent, a sharp DG 16 probe can be used to explore along the anatomical landmarks on the pulp floor. Reassessment of the relationship of the internal anatomical features to the external outlines will also help with orientation during a search for orifices that are difficult to locate. In extensively calcified canals transillumination or the use of dye may provide some guidance for orifice identification and instrument progression. Even extensively calcified canals may contain pulp tissue and judicious use of a variety of instruments usually facilitates entry into the canal system. A number of ultrasonically energized instruments have been designed for this purpose. Despite being relatively safe, care must be taken if perforation of the root is to be avoided. Radiographs taken with radiopaque markers in the chamber can help confirm the direction of instrumentation. When using rotary instruments such as Müller burs or long-shank small round high-speed tungstencarbide burs, frequent re-evaluation of bur position visually and/or radiographically will reduce procedural errors. The direction of search can then be adjusted if necessary and the procedure continued.
Furthermore, enlargement of the canal orifices prior to instrumentation facilitates mid-root and apical instrumentation, and enhances irrigation.

WORKING LENGTH DETERMINATION
Planning a final point for instrumentation and filling depends on the philosophy of treatment, while establishment of this point can be determined in a number of ways. It is necessary to establish the length of the tooth accurately during root canal treatment. The most widely accepted method for establishing working length has been the use of radiographs.


In a tooth with an extensively calcified canal (a) a check radiograph with a probe in the base of the cavity will provide guidance for instrument progression. (b) A later radiograph confirms that the file is in the root canal.

In this method, an estimated working length is initially established by measuring from an accurate, non distorted, preoperative radiograph. A file, preferably ISO size 15 or greater, is then placed to the estimated working length and a second radiograph is exposed. If the tip of the file is within 1 mm of the ideal location then the radiograph can be accepted as an accurate representation of the tooth length. If adjustments of 2 mm or more need to be made, working length should be reconfirmed with a new radiograph. This method usually provides acceptable results. However, radiographs are frequently difficult to interpret especially in posterior teeth. In addition it is widely accepted that the apical foramen may be distant from the radiographic apex further confusing interpretation. Electronic apex locators work on the principle that the impedance between the periodontal membrane and the oral mucosa is constant at 6.5 k 􀀱 .
Recent apex locators (Root ZX, AFA, Justy, Endex- Plus) have been reported to be accurate to within 0.5 mm in >90% of cases. The apex locator is significantly more reliable than the radiograph for determining working length. As a consequence of their accuracy, apex locators allow for a reduction in the number of radiographs necessary to determine the working length especially in teeth where the apex is difficult to visualize on the radiograph. These findings indicate that apex locators should be regarded as the primary means of determining the working length during endodontic procedures. Moreover, in a recent long-term retrospective study in which an apex locator was the sole determinant of working length in infected root canals with periradicular lesions, a high success rate was achieved.

ROOT CANAL IRRIGATION
Regardless of the instrumentation technique or system used, the use of irrigants is essential for debridement of the canal system. Consequently the preparation of root canal systems involves both mechanical and chemical components; hence the concept of ‘chemomechanical’ preparation. Irrigation with appropriate solutions contributes to the cleaning of the canal system in several ways


Including:
rinsing of debris;
Lubrication of the canal system which facilitates


Instrumentation;
Dissolution of remaining organic matter;
Antibacterial properties;
Softening and removing the smear layer;
Penetrating into areas inaccessible to instruments thereby extending the cleaning processes.


Ideally the irrigant should be non-toxic and have a low surface tension in addition to being stable, inexpensive and easy to use. Aplethora of irrigants have been used. Currently, the most widely used irrigant is NaOCl, which has both antibacterial and tissue-dissolving properties.
The effectiveness of this irrigant has been shown to depend on its concentration and time of exposure. Higher concentrations of NaOCl have greater tissue-dissolving properties. However, the greater the concentration, the more severe the potential reaction should some of the irrigant be inadvertently forced into the tissues; hence, various concentrations of NaOCl, varying from 0.5% to 5.25%, have been recommended. Those using the lower concentrations are attempting to minimize the postoperative sequelae should irrigant be inadvertently introduced into the tissues, whilst those using the higher concentrations are attempting to maximize the tissue-dissolving and antibacterial properties of the NaOCl. Accidental extrusion of NaOCl into the periradicular tissues may result is tissue damage accompanied by varying degrees of pain, swelling and bruising. To prevent


Procedural errors with NaOCl:
avoid forceful injection of the irrigant;
Use specially designed side-venting needles;
Use carefully in the presence of resorbed or open apices and perforations.


The use of calcium hydroxide as an intracanal medicament between visits has been shown to enhance disinfection following use of NaOCl. This synergism has beneficial effects for the chemomechanical preparation of the canal system. Other irrigants used in root canal chemomechanical preparation include chlorhexidine, iodine potassium iodide (IKI) and electrolytically activated water. During root canal preparation a layer of ‘sludge’ is formed by the action of the instruments against the canal walls. This material is deposited on the canal wall and is called the ‘smear layer’. The smear layer has both organic and inorganic components and exists as a superficial loosely bound layer and a deeper adherent layer. Considerable debate has occurred as to whether or not the smear layer should be removed. Complete removal of the smear layer may open up dentinal tubules to the passage of microorganisms from the root canal into the body of the dentine. On the other hand, failure to remove the smear layer will possibly allow bacteria to remain in the canal system and impairs the adaptation of the root filling to the dentine wall by preventing the movement of filling material into the dentine tubules. Removal of the smear layer is beneficial to root canal sealing , and significantly less microleakage occurs when these ‘smear-free’ canals are filled with thermoplasticized gutta-percha. A very close adaptation of thermoplasticized gutta-percha to the dentine wall has been shown following smear layer removal. Removal of the smear layer is best achieved by irrigating the canal system with NaOCl throughout the preparation procedure to prevent accumulation of debris on the canal walls and to flush out the canal system. A final rinse with 17.5% ethylene diamine tetra-acetic acid (EDTA) is recommended for removal of the inorganic component; EDTA is also produced commercially in a paste form for lubrication during the instrumentation procedure. The effects of chelating agents such as EDTA are self-limiting.
Delivery of the irrigant is usually achieved by placing a side-venting needle 1–2 mm short of the working length of the canal. Alternatively, ultrasonically energized files can be used. Their effectiveness is due to the creation of acoustic micro streaming and to the effective delivery of irrigant to the apical part of the root canal system.

INSTRUMENTATION TECHNIQUES

Access to the apical part of the root canal will largely depend on adequate coronal preparation. All root canal systems are curved in one or more planes with the degree and extent of curvature varying from root to root. Elimination of coronal obstructions will greatly enhance the instrumentation procedures in the apical part of the root. Irrespective of the instrumentation technique used, the apical part of the canal system is invariably the least well-cleaned and prepared part of the root canal system. Contrary to the idealized picture depicted in many texts, the morphology of the apical canal system is complex and highly variable. Five major apical morphological forms have been described. Experimental clearing of roots has confirmed these variations and underscores the importance of a chemomechanical approach to preparation especially in the apical third of the canal system.
Preparation of the root canal system requires considerable skill, particularly in cases with more severely curved canals or complex anatomical features. Despite advances in instrument design, the experience and tactile skills of the operator remain important. Considerable efforts have been devoted to the study of instrument design and metallurgy in an attempt to produce an ideal instrument. The advances in design have been driven, in part by development of new alloys, and in part by an increase in understanding of the anatomy of the root canal system.


Five major apical morphological forms are shown.


Regardless of the instrumentation procedure or instrument type used, the goals of shaping and cleaning of the root canal systems are:
Debridement of the root canal system;
Development of a continuously tapering preparation;
Avoidance of procedural errors.
Maintaining the anatomy of the apical constriction during canal shaping is essential for predictable healing of the apical tissues, in addition to mechanically retaining the filling material within the confines of the canal system. Long-term studies have shown improved success rates when instrumentation and filling procedures are maintained within the canal system approximately at the level of the cemento-dentinal junction.
Historically, canal preparation techniques have included the standardized and serial preparation techniques that focus on achieving a round apical preparation with either a small or minimal taper from apex to coronal aspect of the preparation. In recent decades the concept of the ideal preparation has altered to take into consideration a greater understanding of the natural anatomy of the root canal system moving away from the more rigid mechanistic approach. Canal preparation techniques can be broadly divided into those that adopt an ‘apical to coronal’ preparation procedure and those that adopt a ‘coronal to apical’ approach.

Crowndown technique

Most recently many clinicians have used coronal to apical techniques to clean and shape root canals.
There are several advantages:
Elimination of debris and microorganisms from the more coronal parts of the root canal system thereby preventing inoculation of apical tissues with contaminated debris;
Elimination of coronally placed interferences that might adversely influence instrumentation;
Early movement of large volumes of irrigant and lubricant to the apical part of the canal;
Facilitation of accurate working length determination as coronal curvature is eliminated early in the preparation.
The crowndown and stepback techniques of preparations aim to produce a similar result, i.e. a flared preparation with small apical enlargement. The essentials of the coronal to apical approach to root canal cleaning and shaping are as follows:
Development of straight-line access from the occlusal or lingual surface into the pulp chamber;
Removal of all overhanging ledges from the pulp chamber roof;
Removal of lingual ledges or cervical bulges that form due to the deposition of dentine in the
Cervical part of the tooth;
Development of divergent walls in the pulp chamber from the cavosurface margin to the chamber floor;
cutting of a funnel-shaped preparation, with its narrowest part located in the tooth apically, in a stepwise manner in the coronal, middle and apical parts of the root canal.
The benefits of using the crowndown technique are multiple and greatly influence the achievement of predictable success with root canal treatment. The clinical benefits of the crowndown technique are:
Ease of removal of pulp stones;
Enhanced tactile feedback with instruments by removal of coronal interferences;


The anatomy of the apical constriction must be maintained during canal preparation
enhanced apical movement of instruments into the canal;
Enhanced working length determination due to minimal tooth contact in the coronal third;
Increased space for irrigant penetration and debridement;
Rapid removal of pulp tissue located in the coronal third;
Straight-line access to root curves and canal junctions;
Enhanced movement of debris coronally;
Decreased deviation of instruments in canal curvatures by reducing root wall contact;
Decrease in canal blockages;
Minimization of instrument separation by reducing contact with canal walls;
Predictable quality of canal shaping;
Predictable quality of canal cleaning;
Faster preparation which may allow one-visit root canal treatment.


The biological benefits of the crowndown technique are:
Rapid removal of contaminated, infected tissue from the root canal system;
Removal of tissue debris coronally, thereby minimizing pushing debris apically;
Reduction in postoperative pain that may occur with apical extrusion of debris;
Better dissolution of tissue with increased


irrigant penetration;
Easier smear layer removal because of better contact with chelating agents;
Enhanced disinfection of canal irregularities due to irrigant penetration.
The basic steps common to all ‘crown to apical’ techniques involve early coronal and mid-root flaring and enlargement before proceeding to the apical part of the canal. The initial coronal flaring can be completed most efficiently with either Gates- Glidden burs or with rotary NiTi instruments, such as orifice shapers (Dentsply Tulsa Dental, Tulsa, OK, USA) designed specifically for this purpose. Early coronal flaring significantly reduces the change in working length during canal preparation. As an instrument initially moves into the coronal third of the canal, the pathway is enlarged; the approach permits rapid irrigant penetration and facilitates further movement of small instruments deeper into the root canal. This entire process is continued until the working length can be determined easily. This then allows unimpeded placement of instruments to the middle and apical parts of the canal system. Irrigants and lubricants will penetrate more easily and will facilitate passage of instruments in an apical direction. ‘Crown to apical’ instrumentation techniques that have been proposed include the crown-down pressureless technique, the Roane technique, the ‘double flare’ technique [25], and the modified double-flare technique. Numerous protocols have been detailed for use with a crown-down preparation technique. A composite protocol for use with a ‘coronal to apical’ preparation is:
1. Access development to remove cervical bulges in posterior teeth or lingual bulges in anterior teeth.
2. Eliminate pulp chamber obstructions.
3. Gates-Gliddens sizes 4, 3, 2, or orifice shapers to enlarge canal orifices; irrigate.
4. Coronal to mid-root enlargement using instruments from large to small; irrigate.
5. Explore canal and establish working length with small instrument (size 10 or 15) using apex locator and/or radiograph; irrigate.
6. Sizes 10, 15, 20 hand instruments to working length; irrigate.
7. Introduce large files to coronal part of canal; when apical resistance is met the file is removed and cleaned; irrigate.
8. Introduce progressively smaller files deeper into the canal again until resistance is encountered; irrigate.
9. Establish apical preparation size; irrigate.
10. Complete preparation to achieve desired taper.

Stepback technique
The most widely used preparation technique until recently has been the stepback or telescope technique first described in the 1960s and later modified. It replaced earlier non-tapering preparation techniques and aimed to reduce instrument transportation in the apical part. It has been effectively superseded by crowndown techniques. The following are the stages of a stepback preparation.


Stage 1
1. Access.
2. Establish working length with a pathfinder instrument.
3. Lubricate a fine instrument and place to length with a ‘watch-winding’ motion (a watchwinding motion implies a gentle clockwise and anti-clockwise rotation of a file with minimal apical pressure); irrigate.
4. Place the next larger size file to length; instrument circumferentially; irrigate.
5. Repeat the process until a size 25 K-file (or a file two to three sizes larger than the first file that binds at the apex) reaches working length.
Recapitulate between files by placing a small file to working length.
This completes the apical preparation; stage 2 involves flaring of the preparation.


Stage 2
1. Place the next file in the series to a length 1 mm short of the working length; instrument circumferentially, irrigate and recapitulate.
2. Repeat this process placing the next larger file in the series to 2 mm short of the working length; instrument circumferentially, irrigate and recapitulate.
3. Repeat the process with successively larger files at 1 mm increments from the preceding file. It is important not to omit any instrument in the sequence.
4. Complete the coronal preparation with Gates- Glidden burs.
Variations to the classic technique include:
• Initial enlarging of the coronal aspect with Gates-Glidden drills;
• Use of small Gates-Glidden burs in the mid-root level;
• Use of Hedstrom files to flare the preparation.
The stepback approach allowed creation of a small apical preparation with larger instruments used at successively decreasing lengths to create a taper. The taper could be altered by changing the interval between the stepback positions. In other words, the taper of the final preparation could be increased by reducing the stepback intervals from 1 to 0.5mm between each file. The stepback technique has been considered to minimize procedural errors, such as transportation, ledging and apical perforation, over previous techniques.
However despite the advances of the stepback preparation over the standardized preparation in producing a tapered preparation, these ‘apex to coronal’ techniques tended to result in significant apical extrusion of debris. Apical blockage, canal deviation and alteration of working length have also been frequently encountered with the stepback technique. In addition, apical extrusion of debris during root canal instrumentation has been associated with postoperative pain or discomfort.

Calcified canals
The basic principles apply to preparation of calcified canals. As with patent canals, once the access cavity to a calcified canal is completed, the pulp chamber is rinsed with NaOCl. If the orifices are identified as being calcified, an ultrasonically energized tip can be used to loosen debris in the orifice. The tip of the ultrasonic instrument can be used either to activate the solution in the chamber or it can be placed into the calcified orifice in an attempt to provide some initial patency. The use of either a NaOCl or EDTA soak for up to 10 minutes along with the use of an ultrasonic tip in these cases may remove some of the mineralized or partially mineralized tissue in the orifices. A small K-file, or a specific file designed for canal penetration (e.g. Pathfinder, Kerr Sybron), can be used to begin canal penetration. At this point, a small orifice shaper can be used to provide a tapered orifice penetration that facilitates further irrigant penetration and allows for the continued use of small K-files, or in some cases a size 15 0.04 tapered instrument, to penetrate further into the canal. The clinician can return to a small ultrasonic tip to penetrate further into the canal. Gates- Glidden burs will not be beneficial as they have a non-cutting tip. This procedure will take time and patience, and the clinician should resist the temptation to try to drill a canal into the root, as this invariably leads to deviation and potential root perforation.

NICKEL-TITANIUM INSTRUMENTS
Following the introduction of nickel-titanium (NiTi) alloy to endodontic instrument design, many new NiTi hand and rotary instruments have become available. The clinical and mechanical properties of these NiTi instruments have been compared with those of stainless-steel instruments; various aspects of instrument performance in canal preparation such as the efficacy of canal preparation, cleanliness of the canals after preparation, the shaping ability of the instruments and fracture properties of the instruments have been examined. There is a general acceptance that rotary NiTi instruments produce well-shaped canals in an efficient manner with the creation of fewer iatrogenic problems than stainless- steel files. However, direct comparison between stainless-steel and NiTi instruments is difficult unless the instrument design is identical. In addition, most testing procedures have been done in vitro, frequently in plastic simulated canals, and longterm clinical evidence of the superiority of one instrument type is unavailable.

CONTROVERSIES IN ROOT CANAL
CLEANING AND SHAPING
A number of issues remain unresolved concerning endodontic treatment procedures; these include:
• Where should the preparation end?
• When should the preparation end?
• Should apical patency filing be performed?
• Should treatment be completed in one or multiple visits?


Where should the preparation end?
This question was addressed succinctly in a short paper entitled ‘Where should the root filling end?. Current treatment protocols used by many clinicians are frequently based on opinion rather than fact. An illogical belief exists that the quality of treatment provided is determined by the presence of sealer ‘puffs’ visible on a postoperative radiograph: the more the better! There is little or no evidence to support this belief; in fact there is considerable evidence for maintaining all instrumentation procedures and filling material within the root canal system. There should be differentiation between vital teeth, those with infected canals, and retreatment cases, when deciding where to terminate the instrumentation and filling. Based on biological principles and experimental evidence instrumentation should terminate 2–3 mm from the radiographic apex in vital cases. In cases where canals are infected, the position should be 0–2mm from the apex, while in retreatment cases the ideal termination should be at the apical foramen. However, irrespective of the preoperative condition of the canal system, it is recommended that all instrumentation and filling procedures should not extend beyond the apical foramen.
Discussion on the ideal termination of the preparation and filling procedures presupposes the existence of the ‘ideal’ root apex as described by Kuttler; however it has been found that this ideal apical terminus exists in less than half of teeth. Instead, a number of apical anatomical configurations have been described. No apical constriction may be present especially in the presence of any resorptive process. Consequently, it is often very difficult or even impossible to locate either the apical constriction or the apical foramen.


When should the preparation end?
Removal of all microorganisms, tissue and debris is the aim of root canal treatment and hence this can be taken to be the end point of preparation. However, determining when this has been achieved remains difficult clinically. Historically instrumentation procedures have taken little account of canal anatomy, such as fins, webs, anastamoses or apical ramifications. Outdated standardized preparation techniques aimed to enlarge the canal to a predetermined size and circular cross-sectional shape. The presence of white dentine chips has been used as a sign of canal cleanliness; however, a lack of correlation between their presence and the cleanliness of the canal has been demonstrated.Because of the complexities of canal anatomy, the emphasis has shifted to chemomechanical preparation of the canal system. Removal of the smear layer improves disinfection. The import ance of an intracanal dressing of calcium hydroxide has been demonstrated as canals can be rendered bacteria-free. An unanswered question is how long should the irrigant be left in the canal system to achieve adequate disinfection of the canal. This concern has fuelled a further controversy; namely can root canal treatment be completed in one visit or should it be done in multiple visits?


Should apical patency filing be performed?
There are two concepts of patency filing. The first and original concept aimed to remove debris collected during instrumentation from the apical part of the canal. This involved sequentially rotating files two to four sizes larger than the initial apical file at working length, then rotating the largest apical file again after a final irrigation and drying. This was called ‘apical clearing’, and aimed to achieve:
• Better debridement;
• Enhanced filling;
• A more defined apical stop.
Apical clearing is recommended in canals which have been prepared with an apical stop. Further, apical clearing in teeth without an apical stop would increase the chances of overpreparation and overfilling.
The second concept of patency filing refers to the placement of small files to and through the apical constriction. The aim is to allow for creation of a preparation and filling extending fully to the periodontal ligament. Evidence to support this concept is unavailable.


Should treatment be completed in one or multiple visits?
One-visit root canal treatment has assumed a position of controversy for many reasons. Clinical studies have addressed the advantages and disadvantages.
The advantages of one-visit treatment are:
• Reduced number of appointments;
• No risk of intra-appointment microbial recontamination;
• Use of canal space for immediate post-retention.


The disadvantages are:
• Longer appointments may cause patient fatigue;
• Inability to control exudates may prevent completion of the procedure.
Those studies concerning postoperative pain as well as effective healing rates have shown that outcomes are similar, whether completed in one or multiple visits. Many of these studies have used older preparation techniques, which have the potential for less effective canal cleaning. There are some indications and contraindications that should be considered when contemplating this approach to treatment. The indications are:
• Uncomplicated teeth with vital pulps;
• Fractured teeth where aesthetics is important and extensive restoration is indicated;
• Patient unable to return for appointments;
• Patient requires antibiotic prophylaxis or sedation.


Contraindications are:
• Patients with acute apical periodontitis;
• Teeth with severe anatomical anomalies;
• Molars with necrotic pulps and periradicular radiolucencies;
• Root canal retreatment.
One-visit treatment does not sit easily with evidence on canal disinfection in infected cases.



Thursday, September 15, 2011

Common Syndromes and developmental anomalies found in Head and Neck region implication on dental treatments


Important definitions

Malformation definition
A morphologic defect of an organ, part of an organ or large area of the body resulting from a developmental abnormality (intrinsic).
Eg: Cleft lip

Deformation definition
Abnormal form of the body part due to mechanical forces.

Disruption definition
Defect of an organ, part of an organ or large area of the body due to interference with a normal developmental process.
Eg: Amneotic bands leads to amputation
Sequence
Multiple defects occur as a result of single presumed structural abnormality.
Eg: Pierre Robin’s Sequence

Syndrome
Combination of signs and/or symptoms that forms as a distinct clinical picture indicative of a particular disorder.
Eg: Down’s syndrome

Common Syndromes and developmental anomalies found in Head and Neck region
  • Cleft lip and palate
  • Valocardiofacial syndrome
  • Pierre Robin’s syndrome
  • Treacher Collins syndrome
  • Golden har syndrome
  • Apert and Crouzen syndrome
Approch to diagnosis
There are over 3000 known syndromes. But only very few are found in common during dental practice. idea of this post is to explain important clinical features of commonly found syndromes and their implication on dental practice.
History plays a major role in diagnosis of a developmental anomaly. Under history these factors are of uttermost important in diagnosis.
  • Medical pedigree
  • Maternal and paternal age
  • Consanguinity
  • Previous abortions
  • Teratogens (Fetal alcohol syndrome)
These factors should be thoroughly examined during physical examination
  • Compare siblings and other family member’s photographs
  • Major and minor abnormalities
  • Isolated minor anomalies (15%)
  • More than 3 minor anomalies with major anomalies (90%)
  • Mental retardation associated
Down’s syndrome
Etiology: nondisjunction mutation resulting in trisomy of 21 chromosome.
Prevalence 1:700
Down’s syndrome is the most common chromosomal abnormality.
It is associated with maternal age more than 37 years.



Facial characteristics
  • Macroglossia
  • Micrognathia
  • Midface hypoplasia (Class III)
  • Flat occiput
  • Flat nasal bridge
  • Epicanthal fold
  • Up slanting palpebral fissures
  • Progressive enlargement of lips
Airway concerns
Due to midface hypoplasia
Obstructive sleep apnoea
Prevalence: 54-100% down’s patients.
 As a combination of anatomic and functional mechanisms.(midface hypoplasia,macroglossia, etc. and hypotonia of pharyngeal muscles)
Cardiovascular abnormalities found in 40% down’s patints.
ASD,VSD, Tetralogy of fallot’s, PDA
Gastrointestinal abnormalities found in 10-18% of down’s patients.
Malignancies are associated with some down’s cases

Valocardiofacial Syndrome (VCFS)
Autosomal dominant condition. Velocardiofacial syndrome (VCFS) is a genetic condition characterized by abnormal pharyngeal arch development that results in defective development of the parathyroid glands, thymus, and conotruncal region of the heart.
Etiology:  by deletion of chromosome 22
Clinical Features: congenital heart diseases, hyper nasal speech, and cleft palate
Basicranial angle flexion- Therefore longer face
Puffy eyelids
Vascular anomalies are very common
Anomalies of the head and neck region are common.

Treacher collin’s syndrome
Autosomal dominant condition
60% are from new mutation
Characteristics: likely due to abnormal migration of neural crest cells into first and second branchial arch structures.
Usually bilateral and symmetrical
Down slanting eyebrows and palpebral fissures
Retruded mandible

Apert and Crowzen’s syndromes
Belong to family of craniosynostosis
Apert’s syndrome is also called as Acrocephalosyndactyly
Facial Characteristics:
  • Craniosynostosis (coronal sutures fused at birth and head circumference is larger than the average head circumference.
  • Hypertelorism
  • Shallow orbits with Exopthalmus
  • Maxillary hypoplasia causing retruded midface with relative prognathism.
  • Beaked nose
  • Downward slanting palpebral fissures
  • Syndactyly
Airway concerns

Treatment
Fronto orbital advancement surgery can be done and get good protection to eyes. Syndactyly can be corrected with surgical reconstruction.

Pierre Robin’s syndrome
Characterize by triad of micrognathia, Glossoptosis, Cleft palate.
80% syndromic

Mechanism of cleft palate formation
Mandibular deficiency causes hypoplastic and retruded mandible (Micrognathia). Therefore Tongue remains retruded and high in oropharynx causing failure of fusing lateral palatal shelves. This results in cleft palate.
Airway obstruction is a marked feature.
Pierre Robin’s syndrome can be associated with other anatomic and neuromuscular components.

Airway management
Temporizing modalties
Prove positioning
Nasopharyngeal airway
Mandibular traction devices
Tongue lip adhesion.
Tracheostomy done if above not worked
Distraction osteogenisis can be done in infants

Goldenhar syndrome
Features
Facial asymmetry and ear deformity.
Vertebral malformations
Uppereyelid coloborma
Auricular malformations
EAC stenosis
Vascular anomalies during fetal life
Unilateral craniofacial malformations
1st and 2nd arch defects

Other concerns
Hearing concerns in greater than 50% patients
Sensoneural occationally.




Wednesday, September 14, 2011

Osteodystrophies of Oro-maxillo facial Region Clinical Features, Radiological Features, Histological Features and Management

Osteodystrophies definition
Osteodystrophies are disorders of bone other than neoplastic and inflammatory conditions.

Classification of osteodystrophies in OMF region
1.       Fibro cement osseous lesions
2.       Giant cell lesions
3.      Inherited and developmental disorders of bone
4.       Metabolic disorders of bone
5.       Miscellaneous

Fibro cement osseous lesions-Classification

A.Developmental
·         Mono ostotic fibrous dysplasia
·         Polyostatic Fibrous dysplasia
·         Polyostatic fibrous dysplasia with endocrinopathy (Macune Albright’s syndrome)
·         Polyostatic fibrous dysplasia with pigmentation (Jaffe-Lichtenstein syndrome)
·         Polyostatic fibrous dysplasia with myxomas
·         Craniofacial fibrous dysplasia

B.Reactive lesions
·         Hereditary
o   Familaial gigantiform cementoma
·         Non Hereditary
o   Periapical cemento osseous dysplasia
o   Florid cement osseous dysplasia
o   Focal cemento osseous dysplasia

C.Neoplastic
·         Conventional cemento ossifying fibroma
·         Juvenile aggressive cement ossifying fibroma

Fibro osseous lesions
One in which bone is replaced by cellular fibrous tissue which gradually matures with the formation of woven bone, lamellar bone ,or very dense amorphous mineralization.

Diagnosis of fibrocemento osseous lesions
The diagnoses of fibrocemento osseous lesions are done using clinical, radiological and histopathological correlation, not by features in isolation.

Fibrous Dysplasia
A benign self limiting but unencapsulated lesion, normally occurring in young subjects. Fibrous dysplasia clinically presents as a painless swelling of the bone involved. Usually, fibrous dysplasia is a self-limiting disease. Therefore, treatment is only required if there are problems due to local increase in size of the affected bone. Sometimes, an osteosarcoma may arise in fibrous dysplasia.
  • Caused by mutation in the GNAS-1 gene
  • Mutation is not inherited but somatic
  • Mutation of gene in causing different types of fibrous dysplasia depending on the time of mutation.
  • If gene is mutated very early embryonic life (undifferentiated stem cells) it affects osteoblasts, melanocytes and endocrine cells),many affected daughter cells are present in different organs and Albright’s syndrome results.
  • If gene is mutated in later stages (after migration and differentiation of skeletal progenitor cells), it affects multiple bones causing polyostatic fibrous dysplasia.
  • Onset 1st and 2nd decades of life
  • Commonly occurring in maxilla and adjacent bones

Albright’s syndrome
Is a combination of
1.       Polyostotic fibrous dysplasia
2.       Cutaneous pigmentation
3.       Endocrine abnormalities (diabetes mellitus ,precocious puberty)
4.       Premature skeletal maturation

Radiology
The classical appearance is described as orange-skin or groundglass radiopacity without defined borders.
Initially appear as well defined radiolucency, later with indistinct margins. Fine trabeculation forming “Ground Glass” appearance as lesion develops. Jaw swelling with thinning of original cortex.


Monostotic fibrous dysplasia
  • Commener than polyostotic form
  • Give rise to a bony swelling caused by a poorly circumscribed area of fibro osseous proliferation
  • Starts in childhood-undergoes arrest in early childhood
  • Jaws are common sites-when the jaws are involved,a painless,smoothy rounded swelling usually of the maxilla is typical
  • When the mass become large malocclusion occur
  • Lesions affecting the maxilla may spread to involve contiguous skull bones causing deformity of the orbit ,base of  the skull and cranial nerve lesions
  • Radiologically-normal bone trabecullation replaced by ground glass or orange peel pattern.
  • Lesions merge imperceptibly with normal bone at margins

Histopathology

In the jaws, fibrous dysplasia may consist of both woven and lamellar bone, as shown in this photomicrograph taken with the use of partly polarised light to enhance the collagenous scaffold of the bone.

  • Vary with age of the lesion
  • Loose fibrous tissue(Whorled, fascicular,random)
  • The normal bone replaced by fibrous connective tissue containing slender trabecullae of bone
  • Early lesions bony trabeculae do not join each other
  • Trabeculae of bone in the cellular areas show a “Chinese letter appearance”
  • Osteoblasts are scattered throughout the substance of the trabecullar rather than surrounding them
  • Older lesions lamellar maturation reversal lines and parallel arrangement of bony trabeculae(onion skin appearance)
  • Usually becomes inactive with skeletal  maturation


Polypstotic fibrous dysplasia
·         Females>males
·         Histologically and radiologically indistinguishable from monostotic form

Management
Disease is self limiting. Grossly disfiguring lesions need to be excised(Contouring,resectiona dn reconstruction) . This should be delayed if possible until the process become inactive. Small risk of sarcomatous changes in poly ostotic type.

Osseous Dysplasia
Osseous dysplasia is a pathologic process of unknown aetiology located in the tooth-bearing jaw areas in the vicinity of the tooth apices and is thought to arise from the proliferation of periodontal ligament fibroblasts that may deposit bone as well as cementum. The condition occurs in various clinical forms that bear different names. However, all have the same histomorphology: cellular fibrous tissue, trabeculae of woven as well as lamellar bone and spherules of cementum-like material. The ratio of fibrous tissue to mineralized material may vary and it has been shown that these lesions are initially fibroblastic, but over the course of several years may show increasing degrees of calcification. This variation in ratio of soft tissue to hard tissue is reflected in the radiographic appearance; lesions are predominantly radiolucent, predominantly radiodense or mixed.
Osseous dysplasia lacks encapsulation or demarcation,but tends to merge with the adjacent cortical or medullary bone. The several subtypes of osseous dysplasia are distinguished by clinical and radiological features.

Periapical osseous dysplasia occurs in the anterior mandible and involves only a few adjacent teeth.
A similar limited lesion occurring in a posterior jaw quadrant is known as Focal osseous dysplasia.


Florid osseous dysplasia is non-expansile, involves two or more jaw quadrants and occurs in middle-aged black females.


Familial gigantiform cementoma is expansile, involves multiple quadrants and occurs at a young age. This type of osseous dysplasia shows an autosomal dominant inheritance with variable expression, but sporadic cases without a history of familial involvement have also been reported. Simple bone cysts may be seen with florid and focal osseous dysplasia. Osseous dysplasia has to be distinguished from ossifying
fibroma. Osseous dysplasia is a mixed radiolucent- radiodense lesion with ill-defined borders in the tooth-bearing part of the jaws, either localised or occupying large jaw areas depending on the type. In contrast, ossifying fibroma is usually a localised lesion that expands the jaw, and is predominantly radiolucent with radiodense areas. Osseous dysplasia also has to be differentiated from sclerosing osteomyelitis. Sclerotic lamellar bone trabeculae and well-vascularised fibrous tissue with lymphocytes and plasma cells define sclerosing osteomyelitis,
Whereas cementum-like areas and fibrocellular soft tissue are lacking. The various forms of osseous dysplasia do not require treatment unless necessitated by complications such as
Infection of sclerotic bone masses, as may occur in florid osseous dysplasia, or facial deformity, as may be seen in familial gigantiform cementoma.

Management
Management of focal cemental dysplasia is usually difficult because surgical removal resulting in small hemorrhagic gritty fragments.

Cemento ossifying fibroma
Ossifying fibroma , formerly also called cemento-ossifying fibroma is a well-demarcated lesion composed of fibrocellular tissue and mineralised material of varying appearance. It occurs most often in the 2nd through the 4th decades. The lesion shows a predilection for females, is mostly seen in the posterior mandible and may occur multifocally. Chromosomal abnormalities have been observed in ossifying fibromas. Data are still too scarce to determine their pathogenetic significance.
Ossifying fibroma contains both cell-rich and cell-poor areas as well as well-structured bone and amorphous calcifi ed material

Ossifying fibroma may also contain more smoothly contoured bony elements, formerly thought to represent cementum
 Juvenile trabecular ossifying fi broma shows slender bony trabeculae rimmed with osteoblasts that merge with an extremely cellular stroma
At higher magnification, the plump osteoblasts that line the bony trabeculae in juvenile trabecular ossifying fi broma are shown to be a prominent feature

Ossifying fibroma is composed of fibrous tissue that may vary in cellularity from areas with closely packed cells displaying mitotic figures to almost acellular sclerosing parts within one and the same lesion. The mineralized component may consist of plexiform bone, lamellar bone and acellular mineralised material, sometimes all occurring together in one single lesion. Juvenile psammomatoid and juvenile trabecular ossifying fibroma are subtypes. Juvenile trabecular ossifying fibroma consists of cell-rich fibrous tissue with bands of cellular osteoid together with slender trabeculae of plexiform bone lined by a dense rim of enlarged osteoblasts. Sometimes these trabeculae may anastomose to form a lattice. Mitoses are present, especially in the cell-rich areas. Also, multinucleated giant cells, pseudocystic stromal degeneration and haemorrhages may be present. Due to its cellularity and mitotic activity, the lesion may be confused with osteosarcoma. However, atypical cellular features or abnormal mitotic figures are not seen.
Moreover, the lesion is demarcated from its surroundings. Juvenile psammomatoid ossifying fibroma is characterized by a fibroblastic stroma containing small ossicles resembling psammoma bodies, hence its name. The stroma varies from loose and fibroblastic to intensely cellular. The spherical or curved ossicles are acellular or include sparsely distributed cells. They should not be confused with the cementum-like deposits that are present in conventional ossifying fibroma. These particles have a smooth contour whereas the ossicles in juvenile psammomatoid ossifying fibroma has a peripheral radiating fringe of collagen fibres. Ossicles may coalesce to form trabeculae. Sometimes, juvenile psammomatoid ossifying fibroma contains basophilic, concentrically lamellated particles, as well as irregular thread-like or thorn-like calcified strands in a hyalinised background. Other features such as trabeculae of woven bone as well as lamellar bone, pseudocystic stromal degeneration and haemorrhages resulting
  • Benign neoplasms of the bone
  • Arising exclusively in the jaws,facial bones and skull
  • Typically causes a painless swlling in the mandibular premolar and molar region
  • Females>males
  • Fibro osseoue lesion
  • Has similarities to fibro osseous dysplasia
  • Radiographycally-starts as small radiolucency and expands slowly
  • Calcification develops centrally as the lesion enlarges
  • Most become densely calcified
  • The lesion has a sharply defined margin often within radiolucent rim surrounded by a narrow zone of cortication

Microscopy
  • Well demarcated from surrounding bone
  • Appearances are widely variable degrees of cellularity and scanty calcifications to densely calcified nodules with little stroma
  • The types of calcification

    1. trabecullae of woven bone with osteoblastic rimming
    2. dystrophic calcifications
    3. rounded calcificatons resembling cemmentricles
    4. calcifications grow gradually,fuse and ultimately from a dense mass

histologically indistinguishable from fibrous dysplasia

Juvenile aggressive cemento ossifying fibroma
  • Commener in children
  • The loose fibroblastic stroma contains very fine,lace like trabeculae of immature osteoid entrapping plum osteoblasts
  • Focal collection of  giant cells are common
  • Histological appearance similar to osteoblastoma  or osteosarcoma
  • Radiological features can avoid this misdiagnosis


Benign cementoblastoma
Benign neoplasm of cementum forming cells. The spherical masses of cemntum usually attach to tooth apex.
·         Patients mostly under 25 years
·         Lesion usually attached to apex of mandibular molar or premolar.

Histopathology
·         Dense bulbosity around tooth apex and is encapsulated
·         Mass of mineralized cementum like tissue with numerous resting and reversal lines.
·         Numerous small vascular spaces throughout the mass
·         Partial resorption of the root apex
·         Peripheral cellular zone unmineralized “Cementoid”.

Giant cell lesions

True giant cell lesions
·         Central giant cell granuloma
·         Peripheral giant cell granuloma
·         Broen tumor of hyperparathyroidism
·         Giant cell tumour
·         Cherubism

Lesions that may contain giant cells
·         Paget’s disease
·         Fibrous dysplasia
·         Aneurismal bone cyst

Central giant cell granuloma
  • Benign hyperplastic lesion of unknown aetiology
  • More common in young females over a wide age range
  • Very expensile and may be destructive may penetrate cortical bone and periosteum
  • Solid but appear as unilocular or multilocular cyst like radiolucency
  • Forms in alvelor ridge,anterior to 6s more fequently in the mandible but often in the maxilla
  • No changes in the blood chemistry
  • Treated by curettage
  • Lobulated mass of proliferating vascular connective tissue packed with giant cells

Cherubism
  • Inherited as autosomal dominant triat
  • Jaw swellings appear in infancy
  • Angle regions of mandible affected symmetrically giving typical chubby face
  • Symmetrical involvelment of maxillae also in ore severe cases
  • Radiolographycally lesions appear as multilocular cyst like areas
  • Histologically lesions consist of giant cells in vascular connective tissue
  • Lesions regress with skeletal maturation and normal facial contour restored

Paget’s Disease
Paget’s disease (osteitis deformans) is a common condition affecting particularly the skull, pelvis, vertebral column and femur in people over 40 years of age. The cause is not yet certain, but the presence in many cases of paramyxovirus-like structures seen within osteoclasts has prompted the suggestion that Paget’s disease may be of viral aetiology and the measles virus and canine distemper viruses have been under scrutiny as candidates. The pathological change is one of active bone formation proceeding alongside active bone destruction.
The affected bones are enlarged, porous and deformed. Microscopically, bone formation is seen in
trabeculae of bone with a lining of numerous osteoblasts. A mosaic appearance is formed by the frequent successive deposition of bone, cessation of deposition resulting in thin, blue “cement lines”, followed again by resumption of deposition and its cessation, and so production of further cement lines. Bone destruction is shown by the presence of numerous, large osteoclastic giant cells with Howship’s lacunae. Areas of chronic inflammatory exudate intermixed with the bone are common.
In the temporal bone the petrous apex, the mastoid and the bony part of the Eustachian tube are most frequently affected. The periosteal part of the bony labyrinth is the first to undergo pagetoid changes and the pagetoid changes spread through the bone towards the membranous labyrinth, usually with a sharp line of demarcation between the pagetoid area and the normal bony labyrinth.
 Osteogenisis imperfecta
Osteogenesis imperfecta is a general bone disease with a triad of clinical features: multiple fractures, blue sclera and conductive hearing loss. There is a congenital recessive form in newborns that is often rapidly fatal and a tardive one in adults that is inherited as a mendelian dominant and is more benign. Mutations of type I collagen genes have been established as the underlying cause leading to a general disturbance in the development of collagen, hence the thin sclerae appearing blue as well as poorly formed bone tissue. In the long bones the resorption of cartilage in the development of bone is normal, but the bony trabeculae themselves are poorly formed and the same may be seen in the temporal bone. The ossicles in the tardive form are very thin and subject to fractures. The stapes footplate is also frequently fixed. The disturbance in lamellar bone formation can lead to extreme thinness, dehiscence, and non-union of the stapedial superstructure with the footplate, or thickening with fixation of the footplate. The nature of the bony tissue causing this fixation is problematical. It has been suggested that osteogenesis imperfecta can be associated with otosclerosis so that the fixation is indeed otosclerotic. Otosclerosis, like osteogenesis imperfecta, may indeed be part of a general connective tissue disturbance. Indeed, some cases of clinical otosclerosis may be related to mutations within the COL1A1 gene that are similar to those found in mild forms of osteogenesis imperfecta.
Osteopetrosis
Osteopetrosis (often known as marble bone disease) is a rare disease of bone, in which there is a failure to absorb calcified cartilage and primitive bone due to deficient activity of osteoclasts. A relatively benign form, inherited as a dominant, presents in adults, and a malignant one, inherited as a recessive, in infants and young children. The patients with the benign form often survive to old age and present prominent ontological symptoms. The intermediate, endochondral portion of the otic capsule is swollen and appears as an exaggeratedly thickened form of the normal state. Globuli ossei composed of groups of calcified cartilage cells are normally present in this region, and in osteopetrosis they are greatly increased in number and are arranged into a markedly thickened zone. The periosteal bone is normal. The ossicles are of foetal shape and filled with unabsorbed, calcified cartilage. The canals for the seventh seventh and eighth cranial nerves are greatly narrowed by the expanded cartilaginous and bony tissue and these changes are probably responsible for the characteristic symptoms of facial palsy and hearing loss respectively.
Cleidocranial Dysplasia
Transmitted by autosomal dominant triat. Defect in CBFA-1 (Nuclear protein). Defective formation of clavicles, delayed closure of frontanells,sometimes retrusive mandible. Partial or complete loss of clavicles allow patient to bring shoulder’s together in front of the chest.not only membranous bones but all part of the skeleton is affected.
Radiological features
·         Aplasia or hypoplasia of claicles
·         Skull shows
o   Delayed closure of frontanells
o   Open skull sutures
o   Sunken sagittal suture-sagittal suture
o   Frontal and occipital bossing
o   Widened cranium-
·         Jaws shows
o   Underdeveloped maxilla-maxillary micrognathia
o   Multiple supernumerary teeth-anterior to permanent molars
o   Unerupted or delayed eruption of permanent teeth
o   Prolonged retention of primary teeth
o   Mandibular prognathism-normal in size
o   Sometimes multiple dentigerous cysts.

Achondroplasia
·         Most common type of genetic skeletal disorders
·         Manifest as short limb dawfism
·         Failure of normal cartilage proliferation in the epiphysis and base of the skull
·         Normal intelligence.CNS not affected.

Hyperparathyroidism
·         Two types
·         Primary and secondary hyperparathyroidism
·         Predominantly in middle aged females
·         Excessive parathomone secreting adenomas
·         Present with generalized osteoclastic activity with fibrosis of marrow
·         In addition, focal areas of bone resorption result in brown tumour formation.
·         Usually present with giant cell epulis and cystic lesions.

Management
Surgical removal of adenoma and subtototal excision of hyperplasia

Rickets and osteomalacia
·         Due to deficiency or resistance to Vitamin D
·         Present with reduced bone density and failure of bone mineralaization.

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